12.5 C
New York
Thursday, August 13, 2020
Home News Scientists discover way to eliminate chemotherapy side effects in mice

Scientists discover way to eliminate chemotherapy side effects in mice

Anyone who has been through cancer, or had a loved one battle it, will be grateful that we live in a world in which chemotherapy exists. One thing they probably won’t be so grateful for are the terrible side effects that accompany chemo — which can include muscle weakness, nausea, dizziness, and more.

Which is why it’s exciting to hear that scientists have published a paper describing how these side effect might be nullified.

“Chemotherapeutic drugs are an effective anti-cancer strategy but come with a number of side effects due to the lack of specificity against cancer cells,” Dr. Marco Demaria, a co-author in the study from the Netherlands’ University of Groningen, told Digital Trends. “During this study, we have shown that a number of these drugs can promote cellular aging, also known as cellular senescence, in many tissues independently of tumors. Eliminating senescent cells from the body using a transgenic mouse model was sufficient to reduce several toxicities associated to the treatment, and improve animals’ healthspan. Moreover, cancer relapse was delayed.”

More: Graphene’s latest miracle? The ability to detect cancer cells

In other words, in animal tests with mice suffering from cancer, the symptoms of four common chemotherapy drugs (doxorubicin, cisplatin, paclitaxel and temozolomide) could be gotten rid of by giving them drugs to kill the senescent cells.

As to the billion dollar question of whether similar findings can be extrapolated to humans, there is reason to be optimistic. The researchers discovered that a higher number of senescent cells pre-chemotherapy correlated with increased fatigue after treatment in breast cancer human patients: a similar finding to the way that mice behaved.

“We are now planning different studies to expand the correlation between cellular senescence and chemotherapy,” Demaria continued. “Our goal is to develop compounds that could interfere with senescent cells to generate combinatorial treatments with low toxicities and high efficacy. However, we need to keep in consideration that senescent cells cover a number of beneficial functions for the organism, and currently we are not able to discriminate and target only the deleterious senescence. Deep characterizations of the different types of senescent cells are needed to design drugs for human treatment.”

To put it another way, don’t expect overnight results, but the prognosis is looking positive!


Gmail redesign with Chat, Rooms, and Meet integration begins rolling out

Google is taking on Slack and Microsoft Teams with the new "integrated workspace" in Gmail.What you need to knowGoogle has

England is launching a public trial for its contact tracing app

England is finally launching its contact tracing app...kind of.What you need to knowEngland is launching public testing of its contact

ROCKUBOT: Sterilizing robot kills germs and bacteria

We live in a dangerous time. Well, okay, maybe not dangerous, but a cautious one at the least. Germs and bacteria are everywhere and we’re more aware of it than ever before.We’re routinely wiping things down, washing hands, and cleaning on a more rigorous basis. And a lot of us are also sterilizing the things we touch. UV-C wands and lights are becoming commonplace in many households.The ROCKUBOT, available for just $99, is the sort of home companion that keeps a vigilant eye on your environment. It automatically traverses over surfaces with its UV-C light and ultrasonic wave technology to help eliminate 99.99% of bacteria, germs, viruses, and mites. All in a matter of seconds.The ROCKUBOT has 24 smart sensors that can help it avoid obstacles or power through terrain. And like your smart robot vacuum cleaner, it has a mapping and navigation feature. Similarly, it can also detect slopes, cliffs, and obstacles.Use the ROCKUBOT to clean a bed or room quickly, efficiently, and quietly, too. Or, take it into manual mode and clean smaller items like your phone, tablet, keyboard, and mouse.But Wait, There’s More!Tucked inside of the ROCKUBOT is a 5,000mAh battery. Yes, you can also take this device with you to keep your phone and other gadgets charged on the go.If that’s not enough to pique your interest, maybe you’d like the “Music Playing Version” of the ROCKUBOT. Priced just $108.99, it houses a Bluetooth speaker. It’s a Tom Haverford dream come true.Order Yours TodayPurchase your ROCKUBOT from the AG Deals Store for only $99.99 right now, saving about $30 in the process. Or, for a few bucks more go all-in with the version that houses a Bluetooth speaker. It’s a bigger savings at around $50 off today!Best SellersEarn Credits!For every $25 you spend in the AG Deals Store you get $1 credit added to your account. And, if you refer the deal via social media or an email that results in a purchase, you’ll earn $10 credit in your account.First Time Buying?If this is your first time buying, you are also eligible for 10% discount! Just be sure to subscribe for email updates.Free StuffNot looking to spend any money today? No worries. You can still visit the AndroidGuys section for freebies and pick something anyhow.

Microsoft Surface Duo pre-orders arrive ahead of September 10 availability

Nearly one year after teasing the device, Microsoft has made its Surface Duo official. While it technically works as a phone, Microsoft’s built the unit as an all-purpose multi-tasking product for professionals. Indeed, it’s like a shrunken down Surface experience that just happens to work as a phone, too.Powered by Android 10, the device features a pair of 5.6-inch OLED displays connected by a narrow 360-degree hinge. Together they form an 8.1-inch display.As one might expect, users can run multiple apps at the same time. Run them side-by-side and you’ll dial up the productivity. Or, in select instances, expand the app to let it take advantage of the larger tablet-like space.Microsoft has taken steps to customize the software and suite of apps, giving it a blend of the best of Android and Windows. Included are Office, Outlook, OneNote, Edge, and a host of other titles, many of which are built with two screens in mind.Key hardware includes a Qualcomm Snapdragon 855 processor, 6GB RAM,and a choice of 128GB/256GB storage.Additionally, the Surface Duo has USB-C, video output via DisplayPort HDMI, a fingerprint reader, and an 11-megapixel camera with 1080p video conferencing/4K video capture. A 3,577mAh battery runs the show and supports 18W fast charging.As a company, we are focused on delivering purposeful innovation – pushing the boundaries of existing categories to not just move technology forward, but to move people forward.While it doesn’t have the hardware that rivals flagship phones, the Microsoft Surface Duo is more about the capabilities. It’s definitely not for everyone and has a very targeted audience.The Surface Duo will launch September 10 with a $1,399 starting price. It supports 4G networks for AT&T, Verizon, and T-Mobile. Pre-orders are available now at Microsoft’s website.